[CRS_META] Fw: [CR] Johns Hopkins and American Diabetes Assoc Study with over-weight Type 2 diabetics

[Al Pater]

The below message appears from the information provided to be an 
advertisement.  A similar message from the same person was provided 
recently, as I recall.

http://www.medifast1.com/weightloss/science.asp

http://Hygeia.tsfl.com

LinksCheskin LJ, Mitchell AM, Jhaveri AD, Mitola AH, Davis LM, Lewis RA, Yep 
MA, Lycan TW.
Efficacy of meal replacements versus a standard food-based diet for weight 
loss in type 2 diabetes: a controlled clinical trial.
Diabetes Educ. 2008 Jan-Feb;34(1):118-27.
PMID: 18267998

Abstract

Purpose

The purpose of this study is to compare the efficacy of a portion-controlled 
meal replacement diet (PCD) to a standard diet (SD) based on recommendations 
by the American Diabetes Association in achieving and maintaining weight 
loss among obese participants with type 2 diabetes.

Methods

This study is a university-based, controlled clinical trial. Participants 
were 119 men and women with diabetes with a body mass index between 25 and 
40 kg/m2, assigned randomly to one of two 34-week, 75% of predicted energy 
need diets (portion controlled or standard, self-selected, food based) and 
then followed by 1-year maintenance.

Results

Using intention-to-treat analyses, weight loss at 34 weeks and weight 
maintenance at 86 weeks was significantly better on PCD versus SD. 
Approximately 40% of the PCD participants lost 5% of their initial weight 
compared with 12% of those on the SD. Significant improvements in 
biochemical and metabolic measures were observed at 34 weeks in both groups. 
The retention rate and self-reported ease of adherence in the PCD group were 
significantly higher throughout the study.

Conclusions

A diet using portion-controlled meal replacements yielded significantly 
greater initial weight loss and less regain after 1 year of maintenance than 
a standard, self-selected, food-based diet. As PCDs may help obese patients 
with type 2 diabetes adhere to a weight control program, diabetes educators 
may consider recommending them as part of a comprehensive approach to weight 
control.

...

Participants were prescribed either a 25% energy-deficit diet in accordance 
with standard ADA recommendations (standard diet [SD]) or an equicaloric, 
portion-controlled diet using Medifast Plus for Diabetics (Medifast, Inc, 
Owings Mills, MD) meal replacements (portion-controlled diet [PCD]). ...

...

Supported by a grant from Medifast, Inc. ... Dr Lisa Davis ... is now an 
employee of Medifast. Parts of this work were presented as an abstract at 
the 2005 American Diabetes Association Annual Scientific Meeting, San Diego, 
California.

-- Al Pater, alpater at SHAW.ca

From: <kenja777 at comcast.net>
To: <cr at lists.calorierestriction.org>
Sent: Saturday, May 24, 2008 2:15 PM


> The program I work with medical grade foods that are very low fat 1 to 3 g 
> (9cal/gm), no alcohol (7cal/gm), low carbs about 70 to 80 gms/day and 
> balanced soy and whey protein 70 to 80 gm per day.  It is about 
> 10%/45%/45%.  Most of the foods have water washed soy because it preserves 
> the natural isoflavins which give added benefits especially for women 
> experiencing menopause.
>
> Dr. Cheskin and others at Johns Hopkins Bloomberg School of Public Health 
> in cooperation with the American Diabetes Association conducted an 86-week 
> trial with 100 over-weight type 2 diabetics.  Half of the group used the 
> Portion Controlled Diet (Medifast meals) and half were given a diet 
> relying on whole foods.  During the 34 week weight loss period twice as 
> many stayed on the PCD because it was easier and they lost twice as much 
> weight.  During the 52-week maintenance period with cross over, both 
> groups had the same maintenance success.  In addition 24% of the PCD group 
> reduced or eliminated diabetes medication including insulin.
>
> The study is published at the ADA web-site at the 65th ADA Annual Meeting 
> and Scientific Session, July 2005.  Enter Cheskin or 1837 in the search 
> box to get the original 
> abstract.http://scientificsessions.diabetes.org/Abstracts/index.cfm?fuseaction=Locator.DisplayAbstractSearch
>
> Below is the abstract.
>
> Long-Term Efficacy of 2 Diet Plans for Type 2 Diabetics on Weight Loss and 
> Weight Maintenance
> Year: 2005
> Abstract Number: 1837-P
> Authors:
>
> LAWRENCE J. CHESKIN, AMY M. MITCHELL, REBECCA A. LEWIS, MARY A. YEP, AMI 
> D. JHAVERI
> Institutions:
>
> Baltimore, MD
> Results:
>
> Background: While weight loss is remarkably effective at controlling type 
> 2 diabetes, the amount of weight loss achieved on diets is typically less 
> for overweight people with type 2 diabetes than for those without 
> diabetes. We compared a portion-controlled, supplement-based diet to a 
> traditional reduced-calorie diet of equal caloric prescription. Methods: 
> 126 overweight (BMI 25-40) type 2 diabetics (age 38-69, mean 55) desiring 
> weight loss were recruited by advertisement and screened. 119 were 
> enrolled (53 males, 66 females) and randomized to either a 25% energy 
> deficit diet similar in composition to standard ADA recommendations (SD), 
> or an equicaloric portion-controlled diet using Medifast Plus for 
> Diabetics food supplements (PCD). An initial weight loss period of 34wks 
> was followed by 52wks maintenance with rerandomization of PCD pts to 
> either 26wks of PCD followed by 26wks of SD (PCD1) or vice versa (PCD2) at 
> a maintenance calorie level. Results: Of patients completing the initi
> al weight loss phase, average weight loss was 6.84% (n=31, mean wt loss=16 
> lbs) for PCD and 3.70% (n=17, mean wt loss= 8.1 lbs) for SD (p=0.039). 61% 
> of PCD pts lost >5% of initial body weight (BW) vs. 23% of SD pts (p<.01). 
> A 10% minimum weight loss was obtained by 29.0% of PCD vs. 5.9% of SD 
> (p=0.04). After the 86wk study, average weight loss for PCD pts was 5.4% 
> (n=16, mean wt loss=13 lbs) vs. 2.5% (n=7, mean wt loss=5.3 lbs) for SD 
> (p=.31). 44% of PCD pts had sustained ¡Ý5% BW loss vs. 14% of SD pts 
> (p=.15). Results were not significantly different between sub-groups of 
> PCD maintenance. Final BW loss was 5.2% (mean=12.9lbs) for PCD1 pts vs. 
> 5.6% (mean=13.1 lbs) for PCD2 pts (p=0.92). Dropout rates were less on the 
> PCD (p=.03). Conclusions: Significantly greater results were achieved by 
> participants in the PCD group in all primary outcome measures, and dropout 
> rates were less on PCD. It is our recommendation that a PCD be considered 
> for type 2 diabetics desiring weight loss, but
> that periodic use of SD during weight maintenance will not adversely 
> affect weight loss efforts.
> Category:
>
> Obesity - Clinical Treatment
>
> Ken Anderson, PE. CEM
> http://Hygeia.tsfl.com
> kenja777 at comcast.net
> 1-877-FAT-2FIT (1-877-328-2348)