[CRS_META] CR list - trim quotes request

[Tim C.]

Hi Derek,

Regarding your post below, can you trim quoted material prior to
submission to list?  This keeps requoted content down and help
improve searching/storage of the list.

Posting guidelines are referenced here.

http://www.calorierestriction.org/node/130

Any resubmitted material will be appreciated.

Thanks,

-Tim C.
cc: Meta list



> ------------------------------------------------------------------------
> Subject:  Re: [CR] Antioxidants ^ mortality?
> From: "Derek Edwards" <derek.edwards at gmail.com>
> Date: Wed, 28 Feb 2007 12:46:01 +1000
> To: "The CR Society Main Discussion List" <cr at lists.calorierestriction.org>
> 
> 
>  An interesting report, Al
> 
> But an item rarely given with these studies is "Who funded the work?"
> 
> "If we don't change, then the future is now" - Jiddu Krishnamurti
> 
> 
> 
> On 28/02/07, *Al Pater* <alpater at shaw.ca <mailto:alpater at shaw.ca>> wrote:
> 
>     Hi All,
> 
>     Surprise.  The pdfs are availed.
> 
>     This Week in JAMA
>     JAMA. 2007;297:779.
>     Antioxidants and Mortality
> 
>     Antioxidants are believed to reduce the risk of several diseases.
>     However,
>     in a previously published article, Bjelakovic and colleagues
>     reported that
>     antioxidant supplements (with the potential exception of selenium)
>     had no
>     effect on gastrointestinal cancer and were associated with an
>     increase in
>     all-cause mortality. In this issue of JAMA, the investigators report
>     results
>     of a systematic literature review to assess the effects of beta
>     carotene,
>     vitamins A and E, ascorbic acid (vitamin C), and selenium on all-cause
>     mortality among participants in primary and secondary disease
>     prevention
>     trials. The authors found that beta carotene, vitamin A, and vitamin E,
>     taken singly or combined with other antioxidant supplements, were
>     associated
>     with increased all-cause mortality.
> 
>     Mortality in Randomized Trials of Antioxidant Supplements for
>     Primary and
>     Secondary Prevention: Systematic Review and Meta-analysis
>     Goran Bjelakovic; Dimitrinka Nikolova; Lise Lotte Gluud; Rosa G.
>     Simonetti;
>     Christian Gluud
>     JAMA. 2007;297:842-857.
> 
>     ABSTRACT
> 
>     Context  Antioxidant supplements are used for prevention of several
>     diseases.
> 
>     Objective  To assess the effect of antioxidant supplements on
>     mortality in
>     randomized primary and secondary prevention trials.
> 
>     Data Sources and Trial Selection  We searched electronic databases and
>     bibliographies published by October 2005. All randomized trials
>     involving
>     adults comparing beta carotene, vitamin A, vitamin C (ascorbic acid),
>     vitamin E, and selenium either singly or combined vs placebo or vs no
>     intervention were included in our analysis. Randomization, blinding, and
>     follow-up were considered markers of bias in the included trials.
>     The effect
>     of antioxidant supplements on all-cause mortality was analyzed with
>     random-effects meta-analyses and reported as relative risk (RR) with 95%
>     confidence intervals (CIs). Meta-regression was used to assess the
>     effect of
>     covariates across the trials.
> 
>     Data Extraction  We included 68 randomized trials with 232 606
>     participants
>     (385 publications).
> 
>     Data Synthesis  When all low- and high-bias risk trials of antioxidant
>     supplements were pooled together there was no significant effect on
>     mortality (RR, 1.02; 95% CI, 0.98-1.06). Multivariate meta-regression
>     analyses showed that low-bias risk trials (RR, 1.16; 95% CI,
>     1.05-1.29) and
>     selenium (RR, 0.998; 95% CI, 0.997-0.9995) were significantly associated
>     with mortality. In 47 low-bias trials with 180 938 participants, the
>     antioxidant supplements significantly increased mortality (RR, 1.05;
>     95% CI,
>     1.02-1.08). In low-bias risk trials, after exclusion of selenium trials,
>     beta carotene (RR, 1.07; 95% CI, 1.02-1.11), vitamin A (RR, 1.16 ;
>     95% CI,
>     1.10-1.24), and vitamin E (RR, 1.04; 95% CI, 1.01-1.07), singly or
>     combined,
>     significantly increased mortality. Vitamin C and selenium had no
>     significant
>     effect on mortality.
> 
>     Conclusions  Treatment with beta carotene, vitamin A, and vitamin E may
>     increase mortality. The potential roles of vitamin C and selenium on
>     mortality need further study.
> 
>     -- Al Pater, alpater at SHAW.ca <mailto:alpater at SHAW.ca>
> 
> 
>     _______________________________________________
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> 
> 
> 
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